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Immunogenetic factors in the incidence of experimental tumors [FATTORI IMMUNOGENETICI NELLA INSORGENZA DI TUMORI SPERIMENTALI]

TitoloImmunogenetic factors in the incidence of experimental tumors [FATTORI IMMUNOGENETICI NELLA INSORGENZA DI TUMORI SPERIMENTALI]
Tipo di pubblicazioneArticolo su Rivista peer-reviewed
Anno di Pubblicazione1993
AutoriDoria, G., Pioli Claudio, Saran Anna, and Covelli V.
RivistaAnnali Italiani di Medicina Interna
Volume8
Paginazione104-107
ISSN03939340
Parole chiaveanimal, article, carcinogenesis, Cell Transformation, Crosses, English Abstract, Experimental, Genetic, immunogenetics, Incidence, Mice, Neoplasms, Neoplastic, Selection (Genetics)
Abstract

The influence of immunological and genetic factors on the appearance of experimental tumors has been studied in mice by means of bidirectional selection. We found that the incidence of lymphomas, solid tumors and chronic nephritis is greater in mice selected for low antibody response than in mice selected for high antibody response. These findings suggest that the genes that control the antibody response also regulate life-span and resistance to neoplastic and inflammatory diseases. Similarly, we are carrying out bidirectional selective breeding to obtain two lines of mice, one sensitive and one resistant to the induction of cutaneous papillomas by chemical carcinogens. The two lines differ notably in terms of both percent of incidence and tumor multiplicity. The results of this study demonstrate clearly that resistance and susceptibility to carcinogenesis are subject to polygenic control.

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URLhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-0027194607&partnerID=40&md5=6b36ba8fe63cd83d57a43c7bb4fcfad5
Citation KeyDoria1993104